Fitting Parameters of a Modified Hill’s Equation and Their Influence on the Shape of the Model Hemoglobin Oxygenation Curve

Oxygen binds to hemoglobin cooperatively, and a correct description of this binding is relevant not only for understanding the mechanisms involved molecular processes but also clinical purposes. Hill’s equation, derived over hundred years ago, still simplest most efficient way perform description. However, in terms accuracy, it inferior Adair´s which contains more parameters. We proposed use modified Hill equation showed that allows accurate oxygen than Adair’s equation. At same time, unlike our model retains physical meaning given original considered analyzed influence parameters on course oxygenation curve presented relationship between fitting other from them form diagram-graph, which, opinion, simplifies perception these estimates can be useful solving number problems traditional analyzing degree cooperative interaction was via suggest newly parameter hmax introduced should regarded as crucial better curve.